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Until the early 1800s
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Until the early 1800s

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Until the early 1800s inoculation referred only to variolation (from variola = smallpox), the predecessor to the smallpox vaccine. The smallpox vaccine, introduced by Edward Jenner in 1798, was called cowpox inoculation or vaccine inoculation (from Latin vacca = cow). Smallpox inoculation continued to be called variolation